The authors observed and analyzed clinically 55 patients with Hodgkin’s disease who
were confirmed and classified histopathologicallu at Presbyterian Medical Center, Chonju,
from March, 1971 to October, 1980.
The following results were obtained :
1. Incidence of Hodgkin’s disease was 0.64% of all malignant neoplasms which were
congirmed at our Hodgkin’s, and 17.8% of all malignant lymphomas during the period
of observation.
2. Sex ration was 2.7 : 1. with male predominance. The highest age incidence was
found in the over 45 year old group(45.5%).
3. Incidence of histopathological subtype by Rye classification was as follows;
lymphocyte predominant was 30.9%, mix cellularity 32.7%, lymphocyte depletion 25.5%
and nodular sclerosis 10.9%, which was of the lowest incidence.
4. Clinical stage by Ann Arbor staging classification as follows; Stage Ⅰ was 29.1%,
Ⅱ 30.9%, Ⅲ 30.9%, Ⅳ 9.1%, and lymphocyte predominant showed more prevalent in
stage Ⅰ∼Ⅱ(82.3%), which lymphocyte depletion was mor frequent in stage Ⅲ∼Ⅳ
(79%).
5. Favorable site of lymph node involovement was cerical in 65.5%, axillary in 27.3%,
and inguinal in 22.7%. Extranodal involvenlent was 20%, involving gastro-intestinal
tract, 18.2% mediastinum, and 5.5% in the nasopharynx.
6. Superficial lymph ncde enlargement was noted in 87.3% of all patients as the initial
subjective symptom, followed by fever, symptoms of involvement of gastrc-intestinal
tract, respiratory system, and general weakness in that order.
7. Lymphangiography as a means of clinical staging shoved 7 positive out of 10, liver
scanning 7 out of 12, and bone marrow aspiration 5 out of 12.
8. Good response 19 treatment showed 69.2% with radiation therapy, 70% with
combinatign chemotherapy, and 71.4% with combination chemotherapy together with
radiation therapy. Especially in lymphocyte predominant cases which shoved 83.3%
response rate with radiation therapy, and 100% response in the 3 cases treated by
means of combination chemotherapy together with radiation therapy.
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